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phenytoin will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to your lower in fentanyl plasma concentrations, not enough efficacy or, maybe, improvement of the withdrawal syndrome in a patient who may h

Check these patients for signs of hypotension after initiating or titrating the dose of morphine sulfate extended-release tablets. In patients with circulatory shock, morphine sulfate extended-release tablets might cause vasodilation which will further more lessen cardiac output and blood pressure. Stay away from using morphine sulfate extended-rel